abstract：:To optimally perform the diversity of metabolic functions that occur within peroxisomes, cells must dynamically regulate peroxisome size, number and content in response to the cell state and the environment. Except for transcriptional regulation little is known about the mechanisms used to perform this complicated fea...

journal_title：Journal of cell science

authors： Yifrach E,Chuartzman SG,Dahan N,Maskit S,Zada L,Weill U,Yofe I,Olender T,Schuldiner M,Zalckvar E

更新日期：2016-11-01 00:00:00

abstract：:Eukaryogenesis - the emergence of eukaryotic cells - represents a pivotal evolutionary event. With a fundamentally more complex cellular plan compared to prokaryotes, eukaryotes are major contributors to most aspects of life on Earth. For decades, we have understood that eukaryotic origins lie within both the Archaea ...

journal_title：Journal of cell science

authors： Dacks JB,Field MC,Buick R,Eme L,Gribaldo S,Roger AJ,Brochier-Armanet C,Devos DP

更新日期：2016-10-15 00:00:00

abstract：:In skeletal muscle, the triad is a structure comprising a transverse (T)-tubule and sarcoplasmic reticulum (SR) cisternae. Triads constitute the basis of excitation-contraction coupling as the cradle of the Ca2+ release complex. We have shown previously that triadin, a member of this complex, has shaping properties on...

journal_title：Journal of cell science

authors： Osseni A,Sébastien M,Sarrault O,Baudet M,Couté Y,Fauré J,Fourest-Lieuvin A,Marty I

更新日期：2016-10-15 00:00:00

abstract：:The sensory functions of cilia are dependent on the enrichment of cilium-resident proteins. Although it is known that ciliary targeting signals (CTSs) specifically target ciliary proteins to cilia, it is still unclear how CTSs facilitate the entry and retention of cilium-resident proteins at the molecular level. We fo...

journal_title：Journal of cell science

authors： Madugula V,Lu L

更新日期：2016-10-15 00:00:00

abstract：:Export out of the endoplasmic reticulum (ER) involves the Sar1 and COPII machinery acting at ER exit sites (ERES). Whether and how cargo proteins are recruited upstream of Sar1 and COPII is unclear. Two models are conceivable, a recruitment model where cargo is actively transported through a transport factor and hande...

journal_title：Journal of cell science

authors： Yonemura Y,Li X,Müller K,Krämer A,Atigbire P,Mentrup T,Feuerhake T,Kroll T,Shomron O,Nohl R,Arndt HD,Hoischen C,Hemmerich P,Hirschberg K,Kaether C

更新日期：2016-10-15 00:00:00

abstract：:The nuclear envelope is much more than a simple barrier between nucleoplasm and cytoplasm. Nuclear envelope bridging complexes are protein complexes spanning both the inner and outer nuclear envelope membranes, thus directly connecting the cytoplasm with the nucleoplasm. In metazoans, they are involved in connecting t...

journal_title：Journal of cell science

authors： Meier I

更新日期：2016-10-01 00:00:00

abstract：:Talin binds to β-integrin tails to activate integrins, regulating cell migration, invasion and metastasis. There are two talin genes, TLN1 and TLN2, encoding talin1 and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear an...

journal_title：Journal of cell science

authors： Qi L,Jafari N,Li X,Chen Z,Li L,Hytönen VP,Goult BT,Zhan CG,Huang C

更新日期：2016-10-01 00:00:00

abstract：:Collective cellular migration within the epithelial layer impacts upon development, wound healing and cancer invasion, but remains poorly understood. Prevailing conceptual frameworks tend to focus on the isolated role of each particular underlying factor - taken one at a time or at most a few at a time - and thus migh...

journal_title：Journal of cell science

authors： Park JA,Atia L,Mitchel JA,Fredberg JJ,Butler JP

更新日期：2016-09-15 00:00:00

abstract：:The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane. GTP hyd...

journal_title：Journal of cell science

authors： Kurokawa K,Suda Y,Nakano A

更新日期：2016-09-01 00:00:00

abstract：:Major histocompatibility complex class I (MHC-I) molecules signal infection or transformation by engaging receptors on T lymphocytes. The spatial organization of MHC-I on the plasma membranes is important for this engagement. We and others have shown that MHC-I molecules, like other membrane proteins, are not uniforml...

journal_title：Journal of cell science

authors： Blumenthal D,Edidin M,Gheber LA

更新日期：2016-09-01 00:00:00

abstract：:Homophilic binding of E-cadherins through their ectodomains is fundamental to epithelial cell-cell adhesion. Despite this, E-cadherin ectodomains have evolved differently in the vertebrate and insect lineages. Of the five rod-like, tandemly aligned extracellular cadherin domains of vertebrate E-cadherin, the tip extra...

journal_title：Journal of cell science

authors： Nishiguchi S,Yagi A,Sakai N,Oda H

更新日期：2016-09-01 00:00:00

abstract：:Excitatory amino acid transporter type 3 (EAAT3, also known as SLC1A1) is a high-affinity, Na(+)-dependent glutamate carrier that localizes primarily within the cell and at the apical plasma membrane. Although previous studies have reported proteins and sequence regions involved in EAAT3 trafficking, the detailed mole...

journal_title：Journal of cell science

authors： Su JF,Wei J,Li PS,Miao HH,Ma YC,Qu YX,Xu J,Qin J,Li BL,Song BL,Xu ZP,Luo J

更新日期：2016-08-15 00:00:00

abstract：:The neuroprotective role of carbon monoxide (CO) has been studied in a cell-autonomous mode. Herein, a new concept is disclosed - CO affects astrocyte-neuron communication in a paracrine manner to promote neuroprotection. Neuronal survival was assessed when co-cultured with astrocytes that had been pre-treated or not ...

journal_title：Journal of cell science

authors： Queiroga CS,Alves RM,Conde SV,Alves PM,Vieira HL

更新日期：2016-08-15 00:00:00

abstract：:Activation and invasion of the vascular endothelium by Staphylococcus aureus is a major cause of sepsis and endocarditis. For endothelial cell invasion, S. aureus triggers actin polymerization through Cdc42, N-WASp (also known as WASL) and the Arp2/3 complex to assemble a phagocytic cup-like structure. Here, we show t...

journal_title：Journal of cell science

authors： Rauch L,Hennings K,Trasak C,Röder A,Schröder B,Koch-Nolte F,Rivera-Molina F,Toomre D,Aepfelbacher M

更新日期：2016-08-01 00:00:00

abstract：:Focal adhesions are complex multi-molecular structures that link the actin cytoskeleton to the extracellular matrix through integrin adhesion receptors and play a key role in regulation of many cellular functions. LAR (also known as PTPRF) is a receptor protein tyrosine phosphatase that regulates PDGF signalling and l...

journal_title：Journal of cell science

authors： Sarhan AR,Patel TR,Cowell AR,Tomlinson MG,Hellberg C,Heath JK,Cunningham DL,Hotchin NA

更新日期：2016-08-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is encoded by multiple mRNA variants whose differential subcellular distribution constitutes a 'spatial code' for local translation of BDNF and selective morphological remodeling of dendrites. Here, we investigated where BDNF translation takes place and what are the signaling p...

journal_title：Journal of cell science

authors： Baj G,Pinhero V,Vaghi V,Tongiorgi E

更新日期：2016-07-15 00:00:00

abstract：:Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C is more nucleoplas...

journal_title：Journal of cell science

authors： West G,Gullmets J,Virtanen L,Li SP,Keinänen A,Shimi T,Mauermann M,Heliö T,Kaartinen M,Ollila L,Kuusisto J,Eriksson JE,Goldman RD,Herrmann H,Taimen P

更新日期：2016-07-15 00:00:00

abstract：:Centrioles organise centrosomes and cilia, and these organelles have an important role in many cell processes. In flies, the centriole protein Ana1 is required for the assembly of functional centrosomes and cilia. It has recently been shown that Cep135 (also known as Bld10) initially recruits Ana1 to newly formed cent...

journal_title：Journal of cell science

authors： Saurya S,Roque H,Novak ZA,Wainman A,Aydogan MG,Volanakis A,Sieber B,Pinto DM,Raff JW

更新日期：2016-07-01 00:00:00

abstract：:The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner mitochondrial membrane, is crucial for adapting mitochondrial function and preserving cellular health. OPA1 governs the delicate balance between fusion and fission in the dynamic mitochondrial network. A disturbance of this bala...

journal_title：Journal of cell science

authors： MacVicar T,Langer T

更新日期：2016-06-15 00:00:00

abstract：:Ovarian follicles are the basic functional units of female reproduction in the mammalian ovary. We show here that the protein a disintegrin and metalloproteinase domain 10 (ADAM10), a cell surface sheddase, plays an indispensable role in controlling primordial follicle formation by regulating the recruitment of follic...

journal_title：Journal of cell science

authors： Feng L,Wang Y,Cai H,Sun G,Niu W,Xin Q,Tang X,Zhang J,Wang C,Zhang H,Xia G

更新日期：2016-06-01 00:00:00

abstract：:Failure to form proper synapses in mechanosensory hair cells, the sensory cells responsible for hearing and balance, leads to deafness and balance disorders. Ribbons are electron-dense structures that tether synaptic vesicles to the presynaptic zone of mechanosensory hair cells where they are juxtaposed with the post-...

journal_title：Journal of cell science

authors： Suli A,Pujol R,Cunningham DE,Hailey DW,Prendergast A,Rubel EW,Raible DW

更新日期：2016-06-01 00:00:00

abstract：:Moving the nucleus to a specific position within the cell is an important event during many cell and developmental processes. Several different molecular mechanisms exist to position nuclei in various cell types. In this Commentary, we review the recent progress made in elucidating mechanisms of nuclear migration in a...

journal_title：Journal of cell science

authors： Bone CR,Starr DA

更新日期：2016-05-15 00:00:00

abstract：:Increased deposition of collagen in extracellular matrix (ECM) leads to increased tissue stiffness and occurs in breast tumors. When present, this increases tumor invasion and metastasis. Precisely how this deposition is regulated and maintained in tumors is unclear. Much has been learnt about mechanical signal transd...

journal_title：Journal of cell science

authors： Zhang K,Grither WR,Van Hove S,Biswas H,Ponik SM,Eliceiri KW,Keely PJ,Longmore GD

更新日期：2016-05-15 00:00:00

abstract：:Semaphorin 3A (Sema3A), a secretory semaphorin, exerts various biological actions through a complex between neuropilin-1 and plexin-As (PlexAs). Sema3A induces retrograde signaling, which is involved in regulating dendritic localization of GluA2 (also known as GRIA2), an AMPA receptor subunit. Here, we investigated a ...

journal_title：Journal of cell science

authors： Yamashita N,Yamane M,Suto F,Goshima Y

更新日期：2016-05-01 00:00:00

abstract：:Activation of the yeast cell wall integrity (CWI) pathway induces an adaptive transcriptional programme that is largely dependent on the transcription factor Rlm1 and the mitogen-activated protein kinase (MAPK) Slt2. Upon cell wall stress, the transcription factor Rlm1 is recruited to the promoters of RLM1 and SLT2, a...

journal_title：Journal of cell science

authors： García R,Sanz AB,Rodríguez-Peña JM,Nombela C,Arroyo J

更新日期：2016-04-15 00:00:00

abstract：:Cadherins and integrins are intrinsically linked through the actin cytoskeleton and share common signaling molecules. Although mechanosensing by the integrin-actin axis has long been appreciated, a growing body of literature now demonstrates that cadherins also transduce and respond to mechanical forces. Mounting evid...

journal_title：Journal of cell science

authors： Mui KL,Chen CS,Assoian RK

更新日期：2016-03-15 00:00:00

abstract：:Selective autophagy entails cooperation between target recognition and assembly of the autophagic apparatus. Target recognition is conducted by receptors that often recognize tags, such as ubiquitin and galectins, although examples of selective autophagy independent of these tags are emerging. It is less known how rec...

journal_title：Journal of cell science

authors： Kimura T,Mandell M,Deretic V

更新日期：2016-03-01 00:00:00

abstract：:A comprehensive analysis of the molecular network of cellular factors establishing and maintaining pluripotency as well as self renewal of pluripotent stem cells is key for further progress in understanding basic stem cell biology. Nanog is necessary for the natural induction of pluripotency in early mammalian develop...

journal_title：Journal of cell science

authors： Münst B,Thier MC,Winnemöller D,Helfen M,Thummer RP,Edenhofer F

更新日期：2016-03-01 00:00:00

abstract：:During angiogenesis, endothelial cells must coordinate matrix proteolysis with migration. Here, we tested whether the focal adhesion scaffold protein Hic-5 (also known as TGFB1I1) regulated endothelial sprouting in three dimensions. Hic-5 silencing reduced endothelial sprouting and lumen formation, and sprouting defec...

journal_title：Journal of cell science

authors： Dave JM,Abbey CA,Duran CL,Seo H,Johnson GA,Bayless KJ

更新日期：2016-02-15 00:00:00

abstract：:Tie2-promoter-mediated loss of peroxisome proliferator-activated receptor gamma (PPARγ, also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension. Vascular disease is associated with loss of PPARγ in pulmonary microvascular endothelial cells (PMVEC); we evaluated the role of PPARγ in PMVE...

journal_title：Journal of cell science

authors： Vattulainen-Collanus S,Akinrinade O,Li M,Koskenvuo M,Li CG,Rao SP,de Jesus Perez V,Yuan K,Sawada H,Koskenvuo JW,Alvira C,Rabinovitch M,Alastalo TP

更新日期：2016-02-15 00:00:00

abstract：:Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular matrix (ECM) of load-bearing tissues such as tendons and cartilage. It provides adaptor functions by bridging different ECM structures. We have previously shown that COMP is also a constitutive component of healthy human skin and ...

journal_title：Journal of cell science

authors： Schulz JN,Nüchel J,Niehoff A,Bloch W,Schönborn K,Hayashi S,Kamper M,Brinckmann J,Plomann M,Paulsson M,Krieg T,Zaucke F,Eckes B

更新日期：2016-02-15 00:00:00

abstract：:The intraerythrocytic developmental cycle of Plasmodium falciparum is completed with the release of up to 32 invasive daughter cells, the merozoites, into the blood stream. Before release, the final step of merozoite development is the assembly of the cortical pellicle, a multi-layered membrane structure. This unique ...

journal_title：Journal of cell science

authors： Kono M,Heincke D,Wilcke L,Wong TW,Bruns C,Herrmann S,Spielmann T,Gilberger TW

更新日期：2016-02-15 00:00:00

abstract：:Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form (pTyr23AnxA2) are involved in malignant cell transformation, metastasis and angiogenesis. Here, we show...

journal_title：Journal of cell science

authors： Grindheim AK,Hollås H,Raddum AM,Saraste J,Vedeler A

更新日期：2016-01-15 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in the development of skeletal muscle. In our previous study, expression of miR-195 and miR-497 were shown to be upregulated during muscle development in pigs. In this study, we investigated the roles of these two miRNAs in myogenesis and analyzed their transcriptional regulatio...

journal_title：Journal of cell science

authors： Wei W,Zhang WY,Bai JB,Zhang HX,Zhao YY,Li XY,Zhao SH

更新日期：2016-01-01 00:00:00

abstract：:The serine/threonine protein phosphatase-1 (PP1) complex is a key regulator of the cell cycle. However, the redundancy of PP1 isoforms and the lack of specific inhibitors have hampered studies on the global role of PP1 in cell cycle progression in vertebrates. Here, we show that the overexpression of nuclear inhibitor...

journal_title：Journal of cell science

authors： Winkler C,De Munter S,Van Dessel N,Lesage B,Heroes E,Boens S,Beullens M,Van Eynde A,Bollen M

更新日期：2015-12-15 00:00:00

abstract：:The adapter protein CD2-associated protein (CD2AP) functions in various signaling and vesicle trafficking pathways, including endosomal sorting and/or trafficking and degradation pathways. Here, we investigated the role of CD2AP in insulin-dependent glucose transporter 4 (Glut4, also known as SLC2A4) trafficking and g...

journal_title：Journal of cell science

authors： Tolvanen TA,Dash SN,Polianskyte-Prause Z,Dumont V,Lehtonen S

更新日期：2015-12-15 00:00:00

abstract：:Maintenance of epithelial polarity depends on the correct localization and levels of polarity determinants. The evolutionarily conserved transmembrane protein Crumbs is crucial for the size and identity of the apical membrane, yet little is known about the molecular mechanisms controlling the amount of Crumbs at the s...

journal_title：Journal of cell science

authors： Lin YH,Currinn H,Pocha SM,Rothnie A,Wassmer T,Knust E

更新日期：2015-12-15 00:00:00

abstract：:The regulation and function of the crucial cell cycle regulator cyclin E (CycE) remains elusive. Unlike other cyclins, CycE can be uniquely controlled by mitochondrial energetics, the exact mechanism being unclear. Using mammalian cells (in vitro) and Drosophila (in vivo) model systems in parallel, we show that CycE c...

journal_title：Journal of cell science

authors： Parker DJ,Iyer A,Shah S,Moran A,Hjelmeland AB,Basu MK,Liu R,Mitra K

更新日期：2015-11-15 00:00:00

abstract：:In many epithelial cells, epidermal growth factor (EGF) augments the epithelial-mesenchymal transition (EMT) that occurs when cells are treated with transforming growth factor β (TGFβ). We demonstrate that this augmentation requires activation of SH2 domain-containing phosphatase-2 (SHP2; also known as PTPN11), a prot...

journal_title：Journal of cell science

authors： Buonato JM,Lan IS,Lazzara MJ

更新日期：2015-11-01 00:00:00

abstract：:Every two years, the French Society for Cell Biology (SBCF) organises an international meeting called 'Imaging the Cell'. This year, the 8th edition was held on 24-26 June 2015 at University of Bordeaux Campus Victoire in the city of Bordeaux, France, a UNESCO World Heritage site. Over the course of three days, the me...

journal_title：Journal of cell science

authors： Moreau V,Cordelières FP,Poujol C,Sagot I,Saltel F

更新日期：2015-11-01 00:00:00